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#424 Indianapolis Colts +6 over Jacksonville Jaguars 12:00 PM CT
The Jaguars dominated the meeting in Week 14 with Daniel Jones injured early in that game as part of a tough late season collapse for a once promising Colts team. Indianapolis played Monday night hosting San Francisco trying to keep its season alive and Indianapolis couldn’t keep pace, with that loss coupled with Houston’s win yesterday ending the playoff hopes for Indianapolis, a tough pull for a team that started 7-1. The Philip Rivers-led offense has brought better returns than most could have expected however and this may still be a competitive team in the final two weeks. Jacksonville served notice to the rest of the AFC last week with an emphatic win at Denver as the Jaguars have won six in a row and Trevor Lawrence has posted his best four games of the season in succession. This is a series that Jacksonville has dominated, going 17-3-1 ATS since 2015 though with a 2-10 S/U run in Indianapolis since 2013 however. This is a rare road favorite number, the largest ever for Jacksonville in Indianapolis and just the fourth time the Jaguars have been laying points at Lucas Oil. Jacksonville’s result last week was a bit of a fluke as Denver had a 6.8-5.1 edge in yards per play while +2 in turnovers. Jacksonville’s convincing road wins in the team’s past two road games were the team’s first road wins by more than one-score since 2023 and this could be a tougher than expected final road game.